Complementary roles of murine Na_V1.7, Na_V1.8 and Na_V1.9 in acute itch signalling.

ABSTRACT: Acute pruritus occurs in various disorders. Despite severe repercussions on quality of life treatment options remain limited. Voltage-gated sodium channels (Na_V) are indispensable for transformation and propagation of sensory signals implicating them as drug targets. Here, Na_V1.7, 1.8 and 1.9 were compared for their contribution to itch by analysing Na_V-specific knockout mice. Acute pruritus was induced by a comprehensive panel of pruritogens (C48/80, endothelin, 5-HT, chloroquine, histamine, lysophosphatidic acid, trypsin, SLIGRL, β-alanine, BAM8-22), and scratching was assessed using a magnet-based recording technology. We report an unexpected stimulus-dependent diversity in Na_V channel-mediated itch signalling. Na_V1.7^-/-

SUBMITTER: Kuhn H 

PROVIDER: S-EPMC7012836 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature