Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model.

ABSTRACT: Chronic glial activation is characterized by increased numbers of activated glial cells, secreting free radicals and cytotoxic cytokines, subsequently causing neuronal damage. In order to investigate the anti-inflammatory activity of Longvida^® Optimised Curcumin (LC), we fed 500 ppm of LC to 2-month-old wild type and GFAP-IL6 mice for 6 months. LC feeding led to a significant reduction in the number of Iba-1⁺ microglia by 26% in the hippocampus and by 48% in the cerebellum, GFAP⁺ astrocytes by 30%, and TSPO⁺ cells by 24% in the hippocampus and by 31% in the cerebellum of the GFAP-IL6 mice. The morphology of the cells was assessed and LC significantly decreased the dendritic length of microglia and the convex area, convex perimeter, dendritic leng

SUBMITTER: Ullah F 

PROVIDER: S-EPMC7012877 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature