Role of Vitamins A and D in BCR-ABL Arf^-/- Acute Lymphoblastic Leukemia.

ABSTRACT: The effects of vitamin A and/or vitamin D deficiency were studied in an Arf^-/- BCR-ABL acute lymphoblastic leukemia murine model. Vitamin D sufficient mice died earlier (p = 0.003) compared to vitamin D deficient (VDD) mice. Vitamin A deficient (VAD) mice fared worst with more rapid disease progression and decreased survival. Mice deficient for vitamins A and D (VADD) had disease progression similar to VAD mice. Regulatory T cells, previously shown to associate with poor BCR-ABL leukemia control, were present at higher frequencies among CD4⁺ splenocytes of vitamin A deficient vs. sufficient mice. In vitro studies demonstrated 1,25-dihydroxyvitamin D (1,25(OH)₂VD₃) increased the number of BCR-ABL ALL cells only when co-cultured with bone marrow st

SUBMITTER: Annu K 

PROVIDER: S-EPMC7012907 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature