The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet.

ABSTRACT: Visceral white adipose tissue (vWAT) expands and undergoes extensive remodeling during diet-induced obesity. Much is known about the contribution of various stromal vascular cells to the remodeling process, but less is known of the changes that occur within the adipocyte as it becomes progressively dysfunctional. Here, we performed a transcriptome analysis of isolated vWAT adipocytes to assess global pathway changes occurring in response to a chronic high fat diet (HFD). The data demonstrate that the adipocyte responds to the HFD by adopting a fibroblast-like phenotype, characterized by enhanced expression of ECM, focal adhesion and cytoskeletal genes and suppression of many adipocyte programs most notably those associated with mitochondria. This study reveals that during obesity the adipo

SUBMITTER: Jones JEC 

PROVIDER: S-EPMC7012923 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature