Effect of the novel histamine H₄ receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss.

ABSTRACT:

Background and purpose

Histamine H₄ receptors are expressed in the peripheral vestibular system, and their selective inhibition improves vertigo symptoms in rats with unilateral vestibular lesions. The effects of SENS-111, a selective oral H₄ receptor antagonist with high affinity to both animal and human receptors, on vertigo symptoms was evaluated in a translational in vivo model of unilateral vestibular loss.

Experimental approach

Pharmacokinetics of SENS-111 in rats was determined to aid dose selection for efficacy testing. Vestibular lesions were induced in rats by unilateral transtympanic injection of kainic acid. The effect of SENS-111 (10 or 20 mg·kg^-1 ) on spontaneous nystagmus was evaluated compared with placebo vehicle using video-

SUBMITTER: Petremann M 

PROVIDER: S-EPMC7012942 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature