The histidine decarboxylase model of tic pathophysiology: a new focus on the histamine H₃ receptor.

ABSTRACT: Histamine dysregulation was implicated as a rare cause of Tourette syndrome and other tic disorders a decade ago by a landmark genetic study in a high density family pedigree, which implicated a hypomorphic mutation in the histidine decarboxylase (Hdc) gene as a rare but high penetrance genetic cause. Studies in Hdc knockout (KO) mice have confirmed that this mutation causes tic-relevant behavioural and neurochemical abnormalities that parallel what is seen in patients and thus validate the KO as a potentially informative model of tic pathophysiology. Recent studies have focused on the potential role of the histamine H₃ receptor in this model, and by association in tic disorders and related neuropsychiatric conditions. The H₃ receptor is up-regulated in the striatum i

SUBMITTER: Pittenger C 

PROVIDER: S-EPMC7012946 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature