Isoprenaline protects intestinal stem cells from chemotherapy-induced damage.

ABSTRACT:

Background and purpose

Damage to intestinal epithelial cells and mucosa limits the effectiveness of several anti-cancer chemotherapeutic agents but the underlying mechanism (s) remain unknown. Little is known of how enteric nervous system regulates proliferation, differentiation, impairment, and regeneration of intestinal stem cells. Here we have investigated the effects of isoprenaline on the damaged intestinal stem cells induced by chemotherapeutic treatments in mice.

Experimental approach

The effects of inhibiting sympathetic and parasympathetic nerves on intestinal stem cells were examined in male C57BL/6J mice. Protection by isoprenaline of intestinal stem cells was assessed in the presence or absence of 5-fluorouracil (5FU) or cisplatin. Cellular apoptosis, cell cycle,

SUBMITTER: Zeng H 

PROVIDER: S-EPMC7012967 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature