Activation of oestrogen receptor α induces a novel form of LTP at hippocampal temporoammonic-CA1 synapses.

ABSTRACT:

Background and purpose

17β estradiol (E2) rapidly regulates excitatory synaptic transmission at the classical Schaffer collateral (SC) input to hippocampal CA1 neurons. However, the impact of E2 on excitatory synaptic transmission at the distinct temporoammonic (TA) input to CA1 neurons and the oestrogen receptors involved is less clear.

Experimental approach

Extracellular recordings were used to monitor excitatory synaptic transmission in hippocampal slices from juvenile male (P11-24) Sprague Dawley rats. Immunocytochemistry combined with confocal microscopy was used to monitor the surface expression of the AMPA receptor (AMPAR) subunit, GluA1 in hippocampal neurons cultured from neonatal (P0-3) rats.

Key results

Here, we show that E2 induces a novel form of LTP at T

SUBMITTER: Clements L 

PROVIDER: S-EPMC7012968 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature