Evaluation of Pathway Activation for a Single Sample Toward Inflammatory Bowel Disease Classification.

ABSTRACT: Since similar complex diseases are much alike in clinical symptoms, patients are easily misdiagnosed and mistreated. It is crucial to accurately predict the disease status and identify markers with high sensitivity and specificity for classifying similar complex diseases. Many approaches incorporating network information have been put forward to predict outcomes, but they are not robust because of their low reproducibility. Several pathway-based methods are robust and functionally interpretable. However, few methods characterize the disease-specific states of single samples from the perspective of pathways. In this study, we propose a novel framework, Pathway Activation for Single Sample (PASS), which utilizes the pathway information in a single sample way to better recognize the differenc

SUBMITTER: Li X 

PROVIDER: S-EPMC7013001 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature