Variability in lutetium-177 SPECT quantification between different state-of-the-art SPECT/CT systems.

ABSTRACT:

Background

Quantitative SPECT imaging in targeted radionuclide therapy with lutetium-177 holds great potential for individualized treatment based on dose assessment. The establishment of dose-effect relations requires a standardized method for SPECT quantification. The purpose of this multi-center study is to evaluate quantitative accuracy and inter-system variations of different SPECT/CT systems with corresponding commercially available quantitative reconstruction algorithms. This is an important step towards a vendor-independent standard for quantitative lutetium-177 SPECT.

Methods

Four state-of-the-art SPECT/CT systems were included: Discovery™ NM/CT 670Pro (GE Healthcare), Symbia Intevo™, and two Symbia™ T16 (Siemens Healthineers). Quantitative accuracy and inter-system

SUBMITTER: Peters SMB 

PROVIDER: S-EPMC7013023 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature