Abnormal Anatomical Rich-Club Organization and Structural-Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease.

ABSTRACT: Emerging research indicates interruptions in the wiring organization of the brain network in Mild cognitive impairment (MCI) and Alzheimer's disease (AD). Due to the important role of rich-club organization in distinguishing abnormalities of AD patients and the close relationship between structural connectivity (SC) and functional connectivity (FC), our study examined whether changes in SC-FC coupling and the relationship with abnormal rich-club organizations during the development of diseases may contribute to the pathophysiology of AD. Structural diffusion-tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) were performed in 38 normal controls (NCs), 40 MCI patients and 19 AD patients. Measures of the rich-club structure and its role in global structural-f

SUBMITTER: Cao R 

PROVIDER: S-EPMC7013042 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature