The association between DXA-derived body fat measures and breast cancer risk among postmenopausal women in the Women's Health Initiative.

ABSTRACT:

Background

Most studies demonstrating an association between excess adiposity and postmenopausal breast cancer have used anthropometric measures, particularly body mass index (BMI). However, more direct body fat measures may more accurately determine the relationship between body fat distribution and breast cancer risk.

Methods

Cox proportional hazards regression models were created to examine the associations of dual-energy x-ray absorptiometry (DXA) body fat measures (at baseline and during follow-up) with breast cancer risk among 10 931 postmenopausal women from the Women's Health Initiative cohort. A total of 639 incident invasive breast cancer cases (including 484 estrogen receptor positive (ER+) cases) were ascertained after a median follow-up of 15.0 years.

Results

SUBMITTER: Arthur RS 

PROVIDER: S-EPMC7013066 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature