SFRP1 in Skin Tumor Initiation and Cancer Stem Cell Regulation with Potential Implications in Epithelial Cancers.

ABSTRACT: Wnt signaling is involved in the regulation of cancer stem cells (CSCs); however, the molecular mechanism involved is still obscure. SFRP1, a Wnt inhibitor, is downregulated in various human cancers; however, its role in tumor initiation and CSC regulation remains unexplored. Here, we used a skin carcinogenesis model, which showed early tumor initiation in Sfrp1^-/- (Sfrp1 knockout) mice and increased tumorigenic potential of Sfrp1^-/- CSCs. Expression profiling on Sfrp1^-/- CSCs showed upregulation of genes involved in epithelial to mesenchymal transition, stemness, proliferation, and metastasis. Further, SOX-2 and SFRP1 expression was validated in human skin cutaneous squamous cell carcinoma, head and neck squamous cell carcinoma, and breast cancer. The data

SUBMITTER: Sunkara RR 

PROVIDER: S-EPMC7013199 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature