Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by CCR2.

ABSTRACT: Aging is associated with inflammation and metabolic syndrome, which manifests in the liver as nonalcoholic fatty liver disease (NAFLD). NAFLD can range in severity from steatosis to fibrotic steatohepatitis and is a major cause of hepatic morbidity. However, the pathogenesis of NAFLD in naturally aged animals is unclear. Herein, we performed a comprehensive study of lipid content and inflammatory signature of livers in 19-month-old aged female mice. These animals exhibited increased body and liver weight, hepatic triglycerides, and inflammatory gene expression compared with 3-month-old young controls. The aged mice also had a significant increase in F4/80⁺ hepatic macrophages, which coexpressed CD11b, suggesting a circulating monocyte origin. A global knockout of the receptor fo

SUBMITTER: Stahl EC 

PROVIDER: S-EPMC7013280 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature