CHG: A Systematically Integrated Database of Cancer Hallmark Genes.

ABSTRACT:

Background

The analysis of cancer diversity based on a logical framework of hallmarks has greatly improved our understanding of the occurrence, development and metastasis of various cancers.

Methods

We designed Cancer Hallmark Genes (CHG) database which focuses on integrating hallmark genes in a systematic, standard way and annotates the potential roles of the hallmark genes in cancer processes. Following the conceptual criteria description of hallmark function the keywords for each hallmark were manually selected from the literature. Candidate hallmark genes collected were derived from 301 pathways of KEGG database by Lucene and manually corrected.

Results

Based on the variation data, we finally identified the hallmark genes of various types of cancer and constructed

SUBMITTER: Zhang D 

PROVIDER: S-EPMC7013921 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature