Mass Spectrometry-Based Metabolomics Analysis of Obese Patients' Blood Plasma.

ABSTRACT: Scientists currently use only a small portion of the information contained in the blood metabolome. The identification of metabolites is a huge challenge because only highly abundant and well-separated compounds can be easily identified in complex samples. However, new approaches that enhance the identification of compounds have emerged; among them, the identification of compounds based on their involvement in a particular biological context is a recent development. In this work, this approach was first applied to identify metabolites in complex samples and, together with metabolite set enrichment analysis, was used for the evaluation of blood plasma from obese patients. The proposed approach was found to provide a statistically sound overview of the biochemical pathways, thus presenting a

SUBMITTER: Lokhov PG 

PROVIDER: S-EPMC7014187 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature