Clozapine reduces infiltration into the CNS by targeting migration in experimental autoimmune encephalomyelitis.

ABSTRACT: BACKGROUND:Atypical antipsychotic agents, such as clozapine, are used to treat schizophrenia and other psychiatric disorders by a mechanism that is believed to involve modulating the immune system. Multiple sclerosis is an immune-mediated neurological disease, and recently, clozapine was shown to reduce disease severity in an animal model of MS, experimental autoimmune encephalomyelitis (EAE). However, the mode of action by which clozapine reduces disease in this model is poorly understood. METHODS:Because the mode of action by which clozapine reduces neuroinflammation is poorly understood, we used the EAE model to elucidate the in vivo and in vitro effects of clozapine. RESULTS:In this study, we report that clozapine treatment reduced the infiltration of peripheral immune cells into the c

SUBMITTER: Robichon K 

PROVIDER: S-EPMC7014621 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature