Presenilin1 exerts antiproliferative effects by repressing the Wnt/β-catenin pathway in glioblastoma.

ABSTRACT:

Background

Glioblastoma and Alzheimer's disease (AD) are the most common and devastating diseases in the central nervous system. The dysfunction of Presenilin1 is the main reason for AD pathogenesis. However, the molecular function of Presenilin1 and its relative mechanism in glioblastoma remain unclear.

Methods

Expression of presenilin1 in glioma was determined by IHC. CCK-8, colony formation, Flow cytometry, Edu staining were utilized to evaluate functions of presenilin1 on glioblastoma proliferation. The mechanism of above process was assessed by Western blotting and cell immunofluorescence. Mouse transplanting glioblastoma model and micro-MRI detection were used to verified presenilin1 function in vivo.

Results

In this study, we found that all grades of glioma mai

SUBMITTER: Yang W 

PROVIDER: S-EPMC7014622 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature