Comparative genome characterization of the periodontal pathogen Tannerella forsythia.

ABSTRACT:

Background

Tannerella forsythia is a bacterial pathogen implicated in periodontal disease. Numerous virulence-associated T. forsythia genes have been described, however, it is necessary to expand the knowledge on T. forsythia's genome structure and genetic repertoire to further elucidate its role within pathogenesis. Tannerella sp. BU063, a putative periodontal health-associated sister taxon and closest known relative to T. forsythia is available for comparative analyses. In the past, strain confusion involving the T. forsythia reference type strain ATCC 43037 led to discrepancies between results obtained from in silico analyses and wet-lab experimentation.

Results

We generated a substantially improved genome assembly of T. forsythia ATCC 43037 covering 99% of the genome in

SUBMITTER: Zwickl NF 

PROVIDER: S-EPMC7014623 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature