The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strains.

ABSTRACT: BACKGROUND:The rate of S68G mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase has increased and is closely related to the K65R mutation among CRF01_AE-infected patients who failed treatment. We aimed to explore the temporal association of S68G and K65R mutations and disclose the role of the former on susceptibility to nucleotide/nucleoside reverse transcriptase inhibitor (NRTI) and viral replication with the K65R double mutations among CRF01_AE-infected patients who failed treatment. METHODS:The occurrence of S68G and K65R mutations was evaluated among HIV-1 of various subtypes in the global HIV Drug Resistance Database. The temporal association of S68G and K65R mutations was analyzed through next-generation sequencing in four CRF01_AE-infected patients who fail

SUBMITTER: Li S 

PROVIDER: S-EPMC7014709 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature