Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese.

ABSTRACT:

Background

Allergic rhinitis (AR) is believed to be a complex genetic disease. The last decade has been marked by the publication of more than 20 genome-wide association studies (GWASs) of AR and associated allergic phenotypes and allergic diseases, which have shown allergic diseases and traits to share a large number of genetic susceptibility loci. The aim of present study was therefore to investigate the highly replicated allergy related genes and variants as candidates for AR in Han Chinese subjects.

Methods

A total of 762 AR patients and 760 control subjects were recruited, and a total of 58 susceptible variants previously reported to be associated with allergic traits were choose for replication.

Results

Logistic regression analyses revealed that in the co-domina

SUBMITTER: Gao Y 

PROVIDER: S-EPMC7014941 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature