Pan-tissue transcriptome analysis of long noncoding RNAs in the American beaver Castor canadensis.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) have roles in gene regulation, epigenetics, and molecular scaffolding and it is hypothesized that they underlie some mammalian evolutionary adaptations. However, for many mammalian species, the absence of a genome assembly precludes the comprehensive identification of lncRNAs. The genome of the American beaver (Castor canadensis) has recently been sequenced, setting the stage for the systematic identification of beaver lncRNAs and the characterization of their expression in various tissues. The objective of this study was to discover and profile polyadenylated lncRNAs in the beaver using high-throughput short-read sequencing of RNA from sixteen beaver tissues and to annotate the resulting lncRNAs based on their potential for orthology with k

SUBMITTER: Kashyap A 

PROVIDER: S-EPMC7014947 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature