Clinical significance of the bronchodilator response in children with severe asthma.

ABSTRACT:

Background

Our objective was to determine those characteristics associated with reversibility of airflow obstruction and response to maximal bronchodilation in children with severe asthma through the Severe Asthma Research Program (SARP).

Methods

We performed a cross-sectional analysis evaluating children ages 6 to 17 years with nonsevere asthma (NSA) and severe asthma (SA). Participants underwent spirometry before and after 180 µg of albuterol to determine reversibility (≥12% increase in FEV₁ ). Participants were then given escalating doses up to 720 µg of albuterol to determine their maximum reversibility.

Results

We evaluated 230 children (n = 129 SA, n = 101 NSA) from five centers across the United States in the SARP I and II cohorts. SA (odds ratio [OR

SUBMITTER: Coverstone AM 

PROVIDER: S-EPMC7015037 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature