Sodium Bicarbonate Supplementation and Urinary TGF-β1 in Nonacidotic Diabetic Kidney Disease: A Randomized, Controlled Trial.

ABSTRACT:

Background and objectives

In early-phase studies of individuals with hypertensive CKD and normal serum total CO₂, sodium bicarbonate reduced urinary TGF-β1 levels and preserved kidney function. The effect of sodium bicarbonate on kidney fibrosis and injury markers in individuals with diabetic kidney disease and normal serum total CO₂ is unknown.

Design, setting, participants, & measurements

We conducted a randomized, double-blinded, placebo-controlled study in 74 United States veterans with type 1 or 2 diabetes mellitus, eGFR of 15-89 ml/min per 1.73 m², urinary albumin-to-creatinine ratio (UACR) ≥30 mg/g, and serum total CO₂ of 22-28 meq/L. Participants received oral sodium bicarbonate (0.5 meq/kg lean body wt per day; n

SUBMITTER: Raphael KL 

PROVIDER: S-EPMC7015087 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature