Olanzapine Versus Placebo in Adult Outpatients With Anorexia Nervosa: A Randomized Clinical Trial.

ABSTRACT:

Objective

This study evaluated the benefits of olanzapine compared with placebo for adult outpatients with anorexia nervosa.

Methods

This randomized double-blind placebo-controlled trial of adult outpatients with anorexia nervosa (N=152, 96% of whom were women; the sample's mean body mass index [BMI] was 16.7) was conducted at five sites in North America. Participants were randomly assigned in a 1:1 ratio to receive olanzapine or placebo and were seen weekly for 16 weeks. The primary outcome measures were rate of change in body weight and rate of change in obsessionality, assessed with the Yale-Brown Obsessive Compulsive Scale (YBOCS).

Results

Seventy-five participants were assigned to receive olanzapine and 77 to receive placebo. A statistically significant treatment

SUBMITTER: Attia E 

PROVIDER: S-EPMC7015155 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature