Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia.

ABSTRACT:

Background

The majority of patients with advanced cancer develop cachexia, a weight loss syndrome that severely reduces quality of life and limits survival. Our understanding of the underlying mechanisms that cause the condition is limited, and there are currently no treatment options that can completely reverse cachexia. Several tumour-derived factors and inflammatory mediators have been suggested to contribute to weight loss in cachectic patients. However, inconsistencies between studies are recurrent. Activin A and interleukin 6 (IL-6) are among the best studied factors that seem to be important, and several studies support their individual role in cachexia development.

Methods

We investigated the interplay between activin A and IL-6 in the cachexia-inducing TOV21G cell l

SUBMITTER: Pettersen K 

PROVIDER: S-EPMC7015233 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature