Skeletal muscle mTORC1 regulates neuromuscular junction stability.

ABSTRACT:

Background

Skeletal muscle is a plastic tissue that can adapt to different stimuli. It is well established that Mammalian Target of Rapamycin Complex 1 (mTORC1) signalling is a key modulator in mediating increases in skeletal muscle mass and function. However, the role of mTORC1 signalling in adult skeletal muscle homeostasis is still not well defined.

Methods

Inducible, muscle-specific Raptor and mTOR k.o. mice were generated. Muscles at 1 and 7 months after deletion were analysed to assess muscle histology and muscle force.

Results

We found no change in muscle size or contractile properties 1 month after deletion. Prolonging deletion of Raptor to 7 months, however, leads to a very marked phenotype characterized by weakness, muscle regeneration, mitochondrial dysfunc

SUBMITTER: Baraldo M 

PROVIDER: S-EPMC7015238 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature