Determination of acrolein-associated T₁ and T₂ relaxation times and noninvasive detection using nuclear magnetic resonance and magnetic resonance spectroscopy.

ABSTRACT: An estimated 3.3 million people are living with a traumatic brain injury (TBI)-associated morbidity. Currently, only invasive and sacrificial methods exist to study neurochemical alterations following TBI. Nuclear magnetic resonance methods-magnetic resonance imaging (MRI) and spectroscopy (MRS)-are powerful tools which may be used non-invasively to diagnose a range of medical issues. These methods can be utilized to explore brain functionality, connectivity, and biochemistry. Unfortunately, many of the commonly studied brain metabolites (e.g., N-acetyl-aspartate, choline, creatine) remain relatively stable following mild to moderate TBI and may not be suitable for longitudinal assessment of injury severity and location. Therefore, a critical need exists to investigate alternative biomarke

SUBMITTER: Vike N 

PROVIDER: S-EPMC7015257 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature