Bioenergetic constraints on the origin of autotrophic metabolism.

ABSTRACT: Autotrophs form the base of all complex food webs and seemingly have done so since early in Earth history. Phylogenetic evidence suggests that early autotrophs were anaerobic, used CO₂ as both an oxidant and carbon source, were dependent on H₂ as an electron donor, and used iron-sulfur proteins (termed ferredoxins) as a primary electron carrier. However, the reduction potential of H₂ is not typically low enough to efficiently reduce ferredoxin. Instead, in modern strictly anaerobic and H₂-dependent autotrophs, ferredoxin reduction is accomplished using one of several recently evolved enzymatic mechanisms, including electron bifurcating and coupled ion translocating mechanisms. These observations raise the intriguing question of why anaerobic auto

SUBMITTER: Boyd ES 

PROVIDER: S-EPMC7015307 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature