Dynamic pulmonary CT perfusion using first-pass analysis technique with only two volume scans: Validation in a swine model.

ABSTRACT:

Purpose

To evaluate the accuracy of a low-dose first-pass analysis (FPA) CT pulmonary perfusion technique in comparison to fluorescent microsphere measurement as the reference standard.

Method

The first-pass analysis CT perfusion technique was validated in six swine (41.7 ± 10.2 kg) for a total of 39 successful perfusion measurements. Different perfusion conditions were generated in each animal using serial balloon occlusions in the pulmonary artery. For each occlusion, over 20 contrast-enhanced CT images were acquired within one breath (320 x 0.5mm collimation, 100kVp, 200mA or 400mA, 350ms gantry rotation time). All volume scans were used for maximum slope model (MSM) perfusion measurement, but only two volume scans were used for the FPA measurement. Both MSM and FPA perfu

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7015394 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature