VAMPr: VAriant Mapping and Prediction of antibiotic resistance via explainable features and machine learning.

ABSTRACT: Antimicrobial resistance (AMR) is an increasing threat to public health. Current methods of determining AMR rely on inefficient phenotypic approaches, and there remains incomplete understanding of AMR mechanisms for many pathogen-antimicrobial combinations. Given the rapid, ongoing increase in availability of high-density genomic data for a diverse array of bacteria, development of algorithms that could utilize genomic information to predict phenotype could both be useful clinically and assist with discovery of heretofore unrecognized AMR pathways. To facilitate understanding of the connections between DNA variation and phenotypic AMR, we developed a new bioinformatics tool, variant mapping and prediction of antibiotic resistance (VAMPr), to (1) derive gene ortholog-based sequence features

SUBMITTER: Kim J 

PROVIDER: S-EPMC7015433 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature