Fungicide Residues Exposure and β-amyloid Aggregation in a Mouse Model of Alzheimer's Disease.

ABSTRACT:

Background

Pesticide residues have contaminated our environment and nutrition over the last century. Although these compounds are present at very low concentrations, their long-term effects on human health is of concern. The link between pesticide residues and Alzheimer's disease is not clear and difficult to establish. To date, no in vivo experiments have yet modeled the impact of this chronic contamination on neurodegenerative disorders.

Objectives

We investigated the impact of fungicide residues on the pathological markers of Alzheimer's disease in a transgenic mouse model.

Methods

Transgenic (J20, hAPPSw/Ind) mice were chronically exposed to a cocktail of residues of cyprodinil, mepanipyrim, and pyrimethanil at 0.1μg/L in their drinking water for 9 months.

SUBMITTER: Lafon PA 

PROVIDER: S-EPMC7015540 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature