Trihalomethanes in Drinking Water and Bladder Cancer Burden in the European Union.

ABSTRACT:

Background

Trihalomethanes (THMs) are widespread disinfection by-products (DBPs) in drinking water, and long-term exposure has been consistently associated with increased bladder cancer risk.

Objective

We assessed THM levels in drinking water in the European Union as a marker of DBP exposure and estimated the attributable burden of bladder cancer.

Methods

We collected recent annual mean THM levels in municipal drinking water in 28 European countries (EU28) from routine monitoring records. We estimated a linear exposure-response function for average residential THM levels and bladder cancer by pooling data from studies included in the largest international pooled analysis published to date in order to estimate odds ratios (ORs) for bladder cancer associated with the me

SUBMITTER: Evlampidou I 

PROVIDER: S-EPMC7015561 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature