Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin.

ABSTRACT:

Background

Tributyltin (TBT) is a persistent and bioaccumulative environmental toxicant. Developmental exposure to TBT has been shown to cause fatty liver disease (steatosis), as well as increased adiposity in many species, leading to its characterization as an obesogen.

Objective

We aimed to determine the long-term effects of developmental TBT exposure on the liver.

Methods

C57BL/6J mice were exposed to a dose of TBT (0.5mg/kg body weight per day; 3.07μM) below the current developmental no observed adverse effect level (NOAEL) via drinking water, or drinking water alone, provided to the dam from preconception through lactation. Sires were exposed during breeding and lactation. Pups from two parity cycles were included in this study. Animals were followed longitudinal

SUBMITTER: Katz TA 

PROVIDER: S-EPMC7015627 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature