Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC7015688 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Zhang Zhe Z Bai Meirong M Barbosa Guilherme Oliveira GO Chen Andrew A Wei Yuehua Y Luo Shuo S Wang Xin X Wang Bingying B Tsukui Tatsuya T Li Hao H Sheppard Dean D Kornberg Thomas B TB Ma Dengke K DK
Science advances 20200212 7
Collagen is the most abundant protein in animals. Its dysregulation contributes to aging and many human disorders, including pathological tissue fibrosis in major organs. How premature collagen proteins in the endoplasmic reticulum (ER) assemble and route for secretion remains molecularly undefined. From an RNA interference screen, we identified an uncharacterized <i>Caenorhabditis elegans</i> gene <i>tmem-131</i>, deficiency of which impairs collagen production and activates ER stress response. ...[more]