Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management.

ABSTRACT: The dual leucine zipper-bearing kinase (DLK) and leucine zipper-bearing kinase (LZK) are evolutionarily conserved MAPKKKs of the mixed-lineage kinase family. Acting upstream of stress-responsive JNK and p38 MAP kinases, DLK and LZK have emerged as central players in neuronal responses to a variety of acute and traumatic injuries. Recent studies also implicate their function in astrocytes, microglia, and other nonneuronal cells, reflecting their expanding roles in the multicellular response to injury and in disease. Of particular note is the potential link of these kinases to neurodegenerative diseases and cancer. It is thus critical to understand the physiological contexts under which these kinases are activated, as well as the signal transduction mechanisms that mediate specific functiona

SUBMITTER: Jin Y 

PROVIDER: S-EPMC7015696 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature