Remote Magnetic Nanoparticle Manipulation Enables the Dynamic Patterning of Cardiac Tissues.

ABSTRACT: The ability to manipulate cellular organization within soft materials has important potential in biomedicine and regenerative medicine; however, it often requires complex fabrication procedures. Here, a simple, cost-effective, and one-step approach that enables the control of cell orientation within 3D collagen hydrogels is developed to dynamically create various tailored microstructures of cardiac tissues. This is achieved by incorporating iron oxide nanoparticles into human cardiomyocytes and applying a short-term external magnetic field to orient the cells along the applied field to impart different shapes without any mechanical support. The patterned constructs are viable and functional, can be detected by T₂ *-weighted magnetic resonance imaging, and induce no alteration to

SUBMITTER: Zwi-Dantsis L 

PROVIDER: S-EPMC7015704 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature