Polarly Localized EccE₁ Is Required for ESX-1 Function and Stabilization of ESX-1 Membrane Proteins in Mycobacterium tuberculosis.

ABSTRACT: Mycobacterium tuberculosis is a slow-growing intracellular bacterium with the ability to induce host cell death and persist indefinitely in the human body. This pathogen uses the specialized ESX-1 secretion system to secrete virulence factors and potent immunogenic effectors required for disease progression. ESX-1 is a multisubunit apparatus with a membrane complex that is predicted to form a channel in the cytoplasmic membrane. In M. tuberculosis this complex is composed of five membrane proteins: EccB₁, EccCa₁, EccCb₁, EccD₁, and EccE₁ In this study, we have characterized the membrane component EccE₁ and found that deletion of eccE₁ lowers the levels of EccB₁, EccCa₁, a

SUBMITTER: Soler-Arnedo P 

PROVIDER: S-EPMC7015709 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature