Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life.

ABSTRACT:

Aims

To describe the pharmacokinetics (PK) and concentration-related effects of dobutamine in critically ill neonates in the first days of life, using nonlinear mixed effects modelling.

Methods

Dosing, plasma concentration and haemodynamic monitoring data from a dose-escalation study were analysed with a simultaneous population PK and pharmacodynamic model. Neonates receiving continuous infusion of dobutamine 5-20 μg kg^-1 min^-1 were included. Left ventricular ejection fraction (LVEF) and cardiac output of right and left ventricle (RVO, LVO) were measured on echocardiography; heart rate (HR), mean arterial pressure (MAP), peripheral arterial oxygen saturation and cerebral regional oxygen saturation were recorded from patient monitors.

Results

Twen

SUBMITTER: Hallik M 

PROVIDER: S-EPMC7015735 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature