Developmental exposure to Pb²⁺ induces transgenerational changes to zebrafish brain transcriptome.

ABSTRACT: Lead (Pb²⁺) is a major public health hazard for urban children, with profound and well-characterized developmental and behavioral implications across the lifespan. The ability of early Pb²⁺ exposure to induce epigenetic changes is well-established, suggesting that Pb²⁺-induced neurobehavioral deficits may be heritable across generations. Understanding the long-term and multigenerational repercussions of lead exposure is crucial for clarifying both the genotypic alterations behind these behavioral outcomes and the potential mechanism of heritability. To study this, zebrafish (Danio rerio) embryos (<2 h post fertilization; EK strain) were exposed for 24 h to waterborne Pb²⁺ at a concentration of 10 μM. This exposed F₀ generation was rais

SUBMITTER: Meyer DN 

PROVIDER: S-EPMC7015790 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature