Multiple channels of DEET repellency in Drosophila.

ABSTRACT:

Background

N,N-Diethyl-meta-toluamide (DEET) is the prophylactic insect repellent used most widely to inhibit insect bites. Despite its use since 1944, the mechanism of DEET repellency remains controversial. Here, we revisited the role of smell and taste in DEET repellence using Drosophila as a model.

Results

Analysis of the responses of individual olfactory receptor neuron (ORN) classes to DEET reveals that 11 ORNs are activated and two are inhibited by this compound. Blocking individual ORN classes in the antenna does not block DEET repellence. This argues against the existence of a single ORN mediating DEET repellence in Drosophila. Activation of all ORCO-expressing neurons using channelrhodopsin favors attraction, not repellence, in behavioral valence. We also demonstrat

SUBMITTER: Guo H 

PROVIDER: S-EPMC7015792 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature