Prevention of tuberculosis in macaques after intravenous BCG immunization.

ABSTRACT: Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide¹. The only available vaccine, BCG (Bacillus Calmette-Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission^1,2. Here we show that intravenous administration of BCG profoundly alters the protective outcome of Mtb challenge in non-human primates (Macaca mulatta). Compared with intradermal or aerosol delivery, intravenous immunization induced substantially more antigen-responsive CD4 and CD8 T cell responses in blood, spleen, bronchoalveolar lavage and lung lymph nodes. Moreover, intravenous immunization induced a high frequency of antigen-responsive T cells across all lung parenchymal tissues. Si

SUBMITTER: Darrah PA 

PROVIDER: S-EPMC7015856 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature