Ultrasound localization microscopy of renal tumor xenografts in chicken embryo is correlated to hypoxia.

ABSTRACT: Ultrasound localization microscopy (ULM) permits the reconstruction of super-resolved microvascular images at clinically relevant penetration depths, which can be potentially leveraged to provide non-invasive quantitative measures of tissue hemodynamics and hypoxic status. We demonstrate that ULM microbubble data processing methods, applied to images acquired with a Verasonics Vantage 256 system, can provide a non-invasive imaging surrogate biomarker of tissue oxygenation status. This technique was applied to evaluate the microvascular structure, vascular perfusion, and hypoxia of a renal cell carcinoma xenograft model grown in the chorioallantoic membrane of chicken embryos. Histological microvascular density was significantly correlated to ULM measures of intervessel distance (R = -0.92,

SUBMITTER: Lowerison MR 

PROVIDER: S-EPMC7015937 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature