Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss.

ABSTRACT: Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not understood, and no validated therapy or prevention exists. NADPH oxidases (NOX), are important sources of reactive oxygen species (ROS) in the cochlea and might therefore be involved in the pathogenesis of ARHL. Here we investigate ARHL in a mouse model. Wild type mice showed early loss of hearing and cochlear integrity, while animals deficient in the NOX subunit p22^phox remained unaffected up to six months. Genes of the excitatory pathway were down-regulated in p22^phox-deficient auditory neurons. Our results demonstrate that NOX activity leads to upregulation of genes of the excitatory pathway, to excitotoxic coch

SUBMITTER: Rousset F 

PROVIDER: S-EPMC7016250 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature