Data on the optimisation of a solid phase extraction method for fractionating estrogen metabolites from small urine volumes.

ABSTRACT: Certain estrogen metabolites have been implicated in the pathophysiology of breast cancer. Moreover, the estrogen metabolite profiles of healthy women and those with (a high risk of) breast cancer differ significantly. The development of an analytical method to determine the relative levels of all the estrogen biotransformation products has been described in van der Berg et al. [1]. An improvement on previously developed methods was the ability to also detect molecules such as sulphate and glucuronide conjugates as well as progesterone, estradiol precursors, and metabolites from the 16-hydroxylation metabolic pathway of estrogens simultaneously with all other estrogen metabolites. The data presented here describe the optimisation of a solid phase extraction method with different fractionat

SUBMITTER: van der Berg CL 

PROVIDER: S-EPMC7016251 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature