Genome-wide analysis and functional prediction of the estrogen-regulated transcriptional response in the mouse uterus†.

ABSTRACT: The ovarian hormones estrogen and progesterone orchestrate the transcriptional programs required to direct functions of the uterus for initiation and maintenance of pregnancy. Estrogen, acting via estrogen receptor alpha, regulates gene expression by activating and repressing distinct genes involved in signaling pathways that regulate cellular and physiological responses including cell division, water influx, and immune cell recruitment. Historically, these transcriptional responses have been postulated to reflect a biphasic physiological response. In this study, we explored the transcriptional responses of the ovariectomized mouse uterus to 17β-estradiol (E2) by RNA-seq to obtain global expression profiles of protein-coding transcripts (mRNAs) and long noncoding RNAs (lncRNAs) following 0

SUBMITTER: Vasquez YM 

PROVIDER: S-EPMC7016285 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature