Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis.

ABSTRACT:

Background

Progressive peritoneal fibrosis is a common complication in patients on long-term peritoneal dialysis (PD). PD-associated peritonitis is a major exacerbating factor. We investigated the anti-fibrotic properties of decorin secreted by peritoneal mesothelial cells.

Methods

Dialysate decorin level in stable PD patients and those with peritonitis was measured. In vitro experiments were conducted to investigate the effect of decorin in fibrotic response in human peritoneal mesothelial cells (HPMC).

Findings

Increasing PD duration was associated with a progressive decrease of dialysate decorin and CA125 levels. Dialysate decorin level correlated with CA125 level. Peritonitis episodes were associated with a massive drop of dialysate decorin, which persisted for ov

SUBMITTER: Jiang N 

PROVIDER: S-EPMC7016379 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature