Somatic mutation landscape reveals differential variability of cell-of-origin for primary liver cancer.

ABSTRACT: Primary liver tissue cancer types are renowned to display a consistent increase in global disease burden and mortality, thus needing more effective diagnostics and treatments. Yet, integrative research efforts to identify cell-of-origin for these cancers by utilizing human specimen data were poorly established. To this end, we analyzed previously published whole-genome sequencing data for 384 tumor and progenitor tissues along with 423 publicly available normal tissue epigenomic features and single cell RNA-seq data from human livers to assess correlation patterns and extended this information to conduct in-silico prediction of the cell-of-origin for primary liver cancer subtypes. Despite mixed histological features, the cell-of-origin for mixed hepatocellular carcinoma/intrahepatic cholan

SUBMITTER: Ha K 

PROVIDER: S-EPMC7016380 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature