Neurospheres Induced from Human Adipose-Derived Stem Cells as a New Source of Neural Progenitor Cells.

ABSTRACT: Human adipose-derived stem cells are used in regenerative medicine for treating various diseases including osteoarthritis, degenerative arthritis, cartilage or tendon injury, etc. However, their use in neurological disorders is limited, probably due to the lack of a quick and efficient induction method of transforming these cells into neural stem or progenitor cells. In this study, we reported a highly efficient and simple method to induce adipose-derived stem cells into neural progenitor cells within 12 hours, using serum-free culture combined with a well-defined induction medium (epidermal growth factor 20 ng/ml and basic fibroblast growth factor, both at 20 ng/ml, with N2 and B27 supplements). These adipose-derived stem cell-derived neural progenitor cells grow as neurospheres, can self

SUBMITTER: Peng C 

PROVIDER: S-EPMC7016463 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature