CXCL5 Modified Nanoparticle Surface Improves CXCR2+ Cell Selective Internalization.

ABSTRACT: Driving nanomaterials to specific cell populations is still a major challenge for different biomedical applications. Several strategies to improve cell binding and uptake have been tried thus far by intrinsic material modifications or decoration with active molecules onto their surface. In the present work, we covalently bound the chemokine CXCL5 on fluorescently labeled amino-functionalized SiO2 nanoparticles to precisely targeting CXCR2+ immune cells. We synthesized and precisely characterized the physicochemical features of the modified particles. The presence of CXCL5 on the surface was detected by z-potential variation and CXCL5-specific electron microscopy immunogold labeling. CXCL5-amino SiO2 nanoparticle cell binding and internalization performances were analyzed in CXCR2+ THP-1 ce

SUBMITTER: Cagliani R 

PROVIDER: S-EPMC7016632 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature